Lycoperine A, A Novel C27N3-Type Pentacyclic Alkaloid from Lycopodium hamiltonii, Inhibiting Acetylcholinesterase

Organic Letters
2006.0

Abstract

A novel C27N3-type pentacyclic Lycopodium alkaloid, lycoperine A (1) consisting of two octahydroquinoline rings and a piperidine ring, was isolated from the club moss Lycopodium hamiltonii. The structure and relative stereochemistry were elucidated on the basis of 2D NMR data and chemical transformation. Lycoperine A (1) exhibited an inhibitory activity against acetylcholinesterase.

DOI： 10.1021/ol052760q

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