Flinderoles A−C: Antimalarial Bis-indole Alkaloids from Flindersia Species

Organic Letters
2009.0

Abstract

(Chemical Equation Presented) With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC50 values between 0.15-1.42 μM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds. © 2009 American Chemical Society.

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