The crystal structures of the dihydrobromide and dihydroiodide of the novel Buxus alkaloid buxenine-G, C25H42N2, have been determined, and the results establish that ring A of the steroidal alkaloid adopts the chair conformation of a cyclohexane and ring C the half-chair conformation characteristic of a cyclohexene. The dihydroiodide crystallizes in the orthorhombic space group P212121 with a = 13.32 ± 0.02.6 = 30.65 ± 0.03, c = 6.96 ± 0.01 Å, and Z = 4, and the dihydrobromide crystallizes in the monoclinic space group P21, with a = 11.012 ± 0.005, b = 7.556 ± 0.004, c = 32.816 ± 0.013 Å. β = 89.8 ± 0.1°, and Z = 4.