A New Cytotoxicβ-Carboline Alkaloid fromGalianthe thalictroides

Planta Medica
2011.0

Abstract

A cytotoxicity-guided fractionation of the roots of Galianthe thalictroides afforded a new beta-carboline alkaloid, 1-(hydroxymeth-yl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-beta-carbolin-1-yl) cyclopentanol, which exhibited strong cytotoxic activity against three human cancer cell lines (MCF-7, 786-0, and UACC62). Its structure was established on the basis of 1D- and 2D-NMR spectroscopic techniques supported by HRMS data.

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