Bonabiline A, a Monoterpenoid 3α-Acyloxytropane from the Roots of Bonamia spectabilis showing M3 Receptor Antagonist Activity

Planta Medica
2006.0

Abstract

Two 3 alpha-acyloxytropanes with unique monoterpenoic acyl moieties, bonabiline A and its anhydro derivative bonabiline B, have been isolated from the roots of Bonamia spectabilis. Their structures were elucidated by detailed spectroscopic analysis. Due to the structural similarity of bonabiline A to atropine/hyoscyamine, the affinity of both bonabilines to the muscarinic M-3 receptor was Studied in the isolated guinea-pig ileum. Bonabiline A (pA(2) 6.65 +/- 0.03) proved to be a more potent antagonist than bonabiline B (pA(2) 5.50 +/- 0.03).

Knowledge Graph

Similar Paper