Transformation of 2,2′-Bimorphine to the Novel Compounds 10-α- S -Monohydroxy-2,2′-Bimorphine and 10,10′-α,α′- S , S ′-Dihydroxy-2,2′-Bimorphine by Cylindrocarpon didymum

Applied and Environmental Microbiology
2001.0

Abstract

Whole-cell suspensions of Cylindrocarpon didymum were observed to transform 2,2'-bimorphine to the compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine. Mass spectrometry and (1)H nuclear magnetic resonance spectroscopy confirmed the identities of these new morphine alkaloids.

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