Four new lipo-alkaloids, named lipoaconitine (10), lipohypaconitine (11), lipomesaconitine (12), and lipodeoxyaconitine (13), have been isolated from Aconiti Tuber (“chuanwu” imported from Si Chuan, China) and their structures elucidated on the basis of chemical and physicochemical evidence. © 1982, The Pharmaceutical Society of Japan. All rights reserved.