Two new alkaloids, picrasidines M (II) and P (III), have been isolated from the root-bark of Picrasma quassioides Bennet. The structure of picrasidine L has been revised from 3-methylcanthin-2,6-dione to 3-methylcanthin-5,6-dione (I). The structures were determined on the basis of spectral analysis and chemical evidence. © 1985, The Pharmaceutical Society of Japan. All rights reserved.