Pyrinodemins B-D, Potent Cytotoxic bis-Pyridine Alkaloids from Marine Sponge Amphimedon sp.

Chemical and Pharmaceutical Bulletin
2000.0

Abstract

New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.

DOI： 10.1248/cpb.48.974

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