Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa

Chemical and Pharmaceutical Bulletin
2011.0

Abstract

Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC(5)(0), 0.9, 21.7, and >50.0 microM, respectively, 2: IC(5)(0) >50.0, 15.7, and 12.4 microM, respectively).

DOI： 10.1248/cpb.59.896

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