Aerial parts of Skimmia laureola yielded a new tyrosinase inhibitor fatty ester, (+)-skimmidiol (1), and a new alkaloid ribaliprenylene (2). The configuration at C-3′ in 1 was established by Horeau's procedure. Compound 1 was screened for its enzyme inhibitory activity against tyrosinase (E.C.1.14.18.1), exhibiting activity with IC50 51.25 ± 1.10165 μM. © 2005 Verlag der Zeitschrift für Naturforschung.