Access to New Cytotoxic Bisindole Alkaloids by a Modified Borch Reductive Amination Process

HETEROCYCLES
2000.0

Abstract

A slight modification of the Borch reductive amination method (delayed addition of NaBH3CN) was applied to an indole aldehyde compound, analog of the natural alkaloid, goniomitine. This reaction led to a series of new cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge.

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