A Total Synthesis of a New Type of Furo[3,2-h]isoquinoline Alkaloid, TMC-120B

HETEROCYCLES
2003.0

Abstract

A total synthesis of a new furo[3,2-h]isoquinoline alkaloid, TMC-120B (2) has been completed in sixteen steps. The key step is the synthesis of 7,8-disubstituted isoquinoline (17) based on the thermal electrocyclic reaction of 1-azahexatriene system involving the benzene 1,2-bond.

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