Structural elucidations of seven novel sesquitcrpene pyridine alkaloids, chuchuhuanines E-I (1), E-II (2), E-III (3), E-IV (4), E-V (5), W-I (6) and 4-deoxyeuonymine (7), which were isolated along with seven known alkaloids from root barks of Maytenus chuchuhuasca Raymond-Hamet et Colas (Celastraceae), are presented. Their structures with a novel dihydro-β-agarofuran type sesquiterpene core, linking several ester moieties and including a fifteen or a sixteen membered macrocyclic diester ring system, were elucidated by mainly spectroscopic methods. © 1994.