Cholinergic agents: 2-oxazolidinone analogues of the acetylcholine-receptor muscarinic agonist pilocarpine

Bioorganic & Medicinal Chemistry Letters
1991.0

Abstract

An oxazolidinone analogue of pilocarpine demonstrates muscarinic agonist-like properties in vitro at the acetylcholine-receptor. Replacement of the carbon alpha to the carbonyl in pilocarpine with a nitrogen represents the most active 2-oxazolidinone, comparable to pilocarpine. Further modifications abolished much of the activity, demonstrating the strict structure activity relationships intrinsic to this series.

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