Cyclic aryl hydroxamic acids: synthesis and inhibition of 5-lipoxygenase

Bioorganic & Medicinal Chemistry Letters
1991.0

Abstract

Cyclic aryl hydroxamic acids 11 were prepared and found to be significantly less potent in inhibiting 5-lipoxygenase than their acyclic analogs 8. This finding provides support to the hypothesis that hydroxamic acids may be inhibiting 5-LO by a mechanism other than simple iron (III) binding.

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