Keto C-glycosides. a new class of antitumor compounds

Bioorganic & Medicinal Chemistry Letters
1991.0

Abstract

A series of 4-keto unsaturated C-glycosides was synthesized from 0-acetyl C-glycosides. These compounds and some parent 2-keto unsaturated C-glycosides were tested for cytotoxic activity against LFC12A cells (Rat hepatocarcinoma cells). C-Glycosides with an acyclic aglycone have not been found cyctotoxic, whereas l-methyl cyclohexenyl and methylene cyclohexenyl C-glycosides possessed ICso values of 9-0.03 FM with 11 being the most potent

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