Configurational variants of hydroxyphenylkainoid: their potent depolarizing activities in the rat central nervous system

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

Four diastereomers of 3-carboxymethyl-4-(2-hydroxyphenyl)proline were synthesized and their depolarizing activities were examined in the isolated rat spinal cord. The (ZS,3S,4S)-isomer was the most potent among them, and the relationship between depolarizing activities and configurational variation was discussed.

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