The synthesis and structure activity relationships of enantiomerically pure hydroxylated oxotremorine derivatives

Bioorganic & Medicinal Chemistry Letters
1992.0

Abstract

The synthesis and radiiligand binding data of optically active hydroxylated oxotremorine derivatives are described. There are significant pharmacological differences between the enantiomers, most notably at the 3- and 4-position of the pyrrolidinone ring. In addition, there appears to be one side of the pyrrolidinone ring that accommodates substituents better than the other (facial selectivity).

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