Thiol and hydroxamic acid containing inhibitors of endothelin converting enzyme

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

A group of peptido-mimetic molecules containing either a thiol or hydroxamic acid moiety were synthesized and evaluated for in vitro inhibition of a putative endothelin converting enzyme (ECE) partially purified from rabbit lung membranes. These compounds were envisioned as analogs of the phosphoramide containing metalloprotease inhibitor phosphoramidon.

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