Synthesis and antibacterial activity of (1′R,5R,6R)-2-tert-butyl-6-(1′-hydroxyethyl)oxapenem-3-carboxylic acid
Bioorganic & Medicinal Chemistry Letters
1993.0
Abstract
The synthesis of (l'R,5R,6R) potassium 2-tertbutyl-6-(l'-hydroxyethyl)oxapenem-3-carboxylate 2 is described. 2 showed excellent in vitro activity against clinical isolates of Staphylococcus aureus.