Synthesis of 4(5)-imidazolyl allylamines and propargylamines as inhibitors of diamine oxidase

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

A series of four side-chain unsaturated histamine analogs were synthesized and evaluated as inhibitors of Diamine Oxidase, (DAO). All four target compounds were potent competitive inhibitors of DAO with Ki values ranging from 0.17 to 7.1 μM.

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