Synthesis of 1-(2-aminopropyl)benzimidazoles, structurally related to the TIBO derivative R82150, with activity against human immunodeficiency virus

Bioorganic & Medicinal Chemistry Letters
1993.0

Abstract

A number of 1-(2-aminopropyl)-2-mercaptobenzimidazoles related to the TIBO derivative R82150 have been prepared and tested for their activity against human immunodeficiency virus type 1 (HIV-1). These compounds were all modest inhibitors of the cytopathic effects of HIV-1 in vitro, but only very weak inhibitors of HIV-1 reverse transcriptase (RT).

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