As part of a plan to uncover new nucleoside based inhibitors of S-adenosyl-L-homocysteine (AdoHcy) hydrolase that are incapable of undergoing competing nucleotide formation, a derivative of 7 deazaaristeromycin (carbocyclic tubercidin) (5) has been prepared that lacks the C-5' hydroxymethyl side-chain. This compound did not exhibit appreciable cytotoxicity or activity against a number of DNA and RNA viruses and was not inhibitory towards AdoHcy hydrolase.