A novel series of substituted 3Hdihydro-pyrimidinonesnes, homologues of SR 47436, was identified as AT1 receptor antagonists. The best compounds showed high affinity for the AT1 receptor (rat liver membrane preparation) with IC%'s in the nanomolar range. Active p.o. in rats in an AII infused model, they ate inacdve in cynomolgus monkeys.