Characterization of the taxol structure-activity profile for the locus of the A-ring side chain

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

Two series of taxol analogs with various N-acyl groups on 3'-phenylisoserine and isoserine A-ring side chains, respectively, were prepared, and their microtubule assembly activities and cytotoxicities toward J774.2 cells were evaluated. Biological activities were adversely affected by the structural modifications investigated, although the 3'-phenylisoserine series was significantly more active than the isoserine series.

Knowledge Graph

Similar Paper

Characterization of the taxol structure-activity profile for the locus of the A-ring side chain
Bioorganic & Medicinal Chemistry Letters 1994.0
Studies toward structure-activity relationships of taxol®: synthesis and cytotoxicity of taxol® analogues with C-2′ modified phenylisoserine side chains
Bioorganic & Medicinal Chemistry Letters 1993.0
Synthesis of biologically active taxol analogs with modified phenylisoserine side chains
Journal of Medicinal Chemistry 1992.0
Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations
Journal of Medicinal Chemistry 1991.0
Characterization of Two Taxol Photoaffinity Analogs Bearing Azide and Benzophenone-Related Photoreactive Substituents in the A-Ring Side Chain
Journal of Medicinal Chemistry 1994.0
Synthesis and Biological Evaluation of C-3'-Modified Analogs of 9(R)-Dihydrotaxol
Journal of Medicinal Chemistry 1994.0
C-3′-N-acyl analogs of 9(R)-dihydrotaxol: synthesis and structure activity relationships
Bioorganic & Medicinal Chemistry Letters 1994.0
Relationships between the structure of taxol analogs and their antimitotic activity
Journal of Medicinal Chemistry 1991.0
Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate)
Bioorganic & Medicinal Chemistry Letters 1992.0
Structure-Activity Studies of Antitumor Taxanes: Synthesis of Novel C-13 Side Chain Homologated Taxol and Taxotere Analogs
Journal of Medicinal Chemistry 1994.0