Possible antineoplastic agents : part 14 - synthesis, activity and QSAR studies of some 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-2-carboxylic acid hydrazides

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

Eight 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-Z-carboxylit acid hydrazides have been synthesized in the QSAR operational scheme and tested for antineoplastic activity in Swiss albino mice with Ehrlich ascites carcinoma (EAC) cell line. The values of percent inhibition of growth, both in ascitic cell count and fluid weight, have been taken as activity parameters. Results indicate that phenylhydrazides are more active than the simple hydrazide analogs. Amongst the phenylhydrazides the unsubstituted compound is the most active one. QSAR has been studied using the LFER model.

Knowledge Graph

Similar Paper

Possible antineoplastic agents : part 14 - synthesis, activity and QSAR studies of some 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-2-carboxylic acid hydrazides
Bioorganic & Medicinal Chemistry Letters 1994.0
Phosphorus-nitrogen compounds. 22. Synthesis and antitumor activity of arylsulfonylhydrazones
Journal of Medicinal Chemistry 1978.0
Synthesis, Structure−Activity Relationships, and Antitumor Studies of 2-Benzoxazolyl Hydrazones Derived from Alpha-(N)-acyl Heteroaromatics
Journal of Medicinal Chemistry 2006.0
Possible anticancer agents: QSAR analogs of glutamamide: Synthesis and pharmacological activity of 1,5-N,N′-disubstituted-2-(substituted benzenesulphonyl) glutamamides
European Journal of Medicinal Chemistry 2009.0
Antimicrobial evaluation of 4-methylsulfanyl benzylidene/3-hydroxy benzylidene hydrazides and QSAR studies
Medicinal Chemistry Research 2012.0
Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents
Bioorganic & Medicinal Chemistry 2007.0
Design, synthesis, antimicrobial, anticancer evaluation, and QSAR studies of 4-(substituted benzylidene-amino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-ones
Medicinal Chemistry Research 2012.0
Synthesis, pharmacological activity and comparative QSAR modeling of 1,5-N,N′-substituted-2-(substituted naphthalenesulphonyl) glutamamides as possible anticancer agents
European Journal of Medicinal Chemistry 2010.0
Synthesis and antitumor activity of β-carboline 3-(substituted-carbohydrazide) derivatives
Bioorganic & Medicinal Chemistry 2011.0
Design, synthesis and biological evaluation of (E)-2-(2-arylhydrazinyl)quinoxalines, a promising and potent new class of anticancer agents
Bioorganic & Medicinal Chemistry Letters 2014.0