Eight 1-(substituted benzenesulphonyl)-5-oxopyrrolidine-Z-carboxylit acid hydrazides have been synthesized in the QSAR operational scheme and tested for antineoplastic activity in Swiss albino mice with Ehrlich ascites carcinoma (EAC) cell line. The values of percent inhibition of growth, both in ascitic cell count and fluid weight, have been taken as activity parameters. Results indicate that phenylhydrazides are more active than the simple hydrazide analogs. Amongst the phenylhydrazides the unsubstituted compound is the most active one. QSAR has been studied using the LFER model.