The above data have demonstrated that HNI and AHA are both suitable substrates for the replacement of methionine in the tetrapeptide CCK₃₀₋₃₃ and the heptapeptides [pGlu⁵]Sub.P₅₋₁₁ and AcSub.P₅₋₁₁. Differences are observed in receptor selectivity when the modified Sub.P analogues are assayed against the three known tachykinin receptor subtypes, and may therefore find use as pharmacological tools.