Methionine replacements in biologically active peptides

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

The above data have demonstrated that HNI and AHA are both suitable substrates for the replacement of methionine in the tetrapeptide CCK₃₀₋₃₃ and the heptapeptides [pGlu⁵]Sub.P₅₋₁₁ and AcSub.P₅₋₁₁. Differences are observed in receptor selectivity when the modified Sub.P analogues are assayed against the three known tachykinin receptor subtypes, and may therefore find use as pharmacological tools.

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