Calcineurin has a very tight-binding pocket for the side chain of residue 4 of cyclosporin

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

Derivatives of cyclosporin A (CsA) at position 4 were synthesised to probe the interaction of the CsA/CypA complex with calcineurin (CaN). Both lipophilic and hydrophilic substituents are detrimental for the immunosuppressive activity, indicating that CaN has a very "tight-binding pocket" for this region.

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