The isolation and in vivo Potent Antitumor activity of clerodane diterpenoid from the oleoresin of the brazilian medicinal plant, copaifera langsdorfi desfon.

Bioorganic & Medicinal Chemistry Letters
1994.0

Abstract

An extremely potent antitumor neo-clerodane diterpene was isolated from the oleoresin of the Brazilian medicinal plant, Copaifera lungsdqii Desfon. This compound was identified as (-) kolavenol 1. The antitumor effect of 1 against IMC carcinoma as determined from the increase in lifespan (I.L.S.) in mice was twice that of 5FU. The structure elucidation and the antitumor activity of the other related compounds 2-6 in this oleoresin were also described

Knowledge Graph

Similar Paper