Red-Al was used to selectively remove the C2 benroate of 7,13-bisTES baccatin (8). Derivatization of the resulting Cz hydroxy compound provided the corresponding p-nitrophenyl carbamate, the p-methoxy and p-nitrobenzoates, and cyclohexyl ester. Attachment of the tax01 side chain to the above four analogs via lactam (IS) followed by desilylation provided five analogs of taxol modified at the Cz position, including a Cl2 cyclic carbonate. These five analogs were less potent than taxol in a tubulin polymerization assay and a cytotoxicity assay against human colon cancer cell line.