Synthesis and antiviral activity of rigid acyclonucleotide analogs

Bioorganic & Medicinal Chemistry Letters
1995.0

Abstract

The synthesis, anti-HIV-1 and anti-herpesvirus activities of new rigid acyclonucleotide analogs are described. 9-[2-methylidene-3-(phosphonomethoxy)propyl]guanine la exhibits in vitro anti-HIV-1 activity similar to that of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Compound la is 9-fold less toxic to human T-lymphoid cells MT-4 than PMEA.

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