Enantiomerically pure synthesis and antiviral evaluation of [(2′S, 3′S)-bis(hydroxymethyl)azetidin-1-yl] purine nucleosides: Analogs of oxetanocin-A
Bioorganic & Medicinal Chemistry Letters
1995.0
Abstract
The enantiomerically pure synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azetidin-l-yl] adenine 9 and -guanine 13 was achieved via construction of the base on the 1-amino-azetidine 4 and their anti-HSV-1 and -2, and anti-HIV-1 activities were evaluated.