Synthesis and pharmacological activities of a novel tripeptide mimetic dopamine prodrug

Bioorganic & Medicinal Chemistry Letters
1995.0

Abstract

D-p-hydroxyphenylglycine-L-proline was attached to L-dopa as delivery tool for improving the oral absorption. This tripeptide prodrug 1 of dopamine was well absorbed in a perfusion study in rat intestine, devoid of dopamine-like side effects on isolated smooth muscles and significantly inhibited the (+) methamphetamine-induced rotation in nigrostriatal-lesioned rats, suggesting of anti-Parkinsonism effect.

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