Isosteric replacement of the indole nucleus by benzothiophene in a series of pyrido[2,3-b]indoles with potential anxiolytic activity

Bioorganic & Medicinal Chemistry Letters
1995.0

Abstract

Isosteric replacement of the indole nucleus in a series of pyrido[2,3-b]indoles e.g. 1 and 2 has provided potent GABA A modulators with potential anxiolytic activity. Both benzothiophene and cycloalkyl fused heterocyclic ring systems are acceptable moieties.

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