Synthesis and antitumor activity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents

Bioorganic & Medicinal Chemistry Letters
1995.0

Abstract

A series of new camptothecin derivatives bearing five-membered ring heterocycle containing substituents in the 10-position were synthesized and evaluated for in vitro cytotoxic activity. Camptothecin derivatives bearing a pyrrole or a thiophene ring were significantly more potent than camptothecin, however those bearing furan were less potent than camptothecin.

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