Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor
Bioorganic & Medicinal Chemistry Letters
1995.0
Abstract
CMI-206, trans-2[3-methoxy-4-propoxy-5(N'-butyl-N'-hydroxyureidyl)phenyl]-5- (3,4,5-trimethoxyphenyl)tetrahydrofuran, was synthesized and was found to antagonize PAF receptor binding and inhibit 5-lipoxygenase activity both in vitro and in vivo.