Structure-activity dependency of new bacterial tryptophanyl tRNA synthetase inhibitors

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Analogues of the aminoacyl tRNA synthetase inhibitor, indolmycin, have been synthesised in which the side chain methyl group is replaced by a wide range of substituents. Their antibacterial and enzyme inhibitory potency is related to steric properties and conformational preferences.

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