Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Homo-N-nucleosides can be efficiently synthesized from 2-deoxyribose. When incorporated in an oligonucleotide, the compounds have a detrimental influence on duplex stability and on the catalytic activity of hammerhead ribozymes. However, homo-N-nucleosides with a guanine or adenine base moiety do exhibit selective antiviral activity against herpes simplex virus (HSV-1 and HSV-2).

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