Synthesis and biological activity of 4′-azido- and 4′-trifluoracetamido-3′-chloro-3′-deamino-4′-deoxydaunorubicin

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

The syntheses of l-O-acetyl-4-azido-3-chloro-L-lyxo-hexopyranose and l-O-acetyl-3-chloro-4 trifluoracetamido-L-lyxo-hexopyranose are described. These aminosugars were successfully employed for the synthesis of 4'-azido- 3'-chioro-3'-deamino-4'-deoxydaunorubicin and 3'-chioro-3'-deamino-4'-deoxy-4' tlLfluoracetamidodannorubicin. The cytotoxicity of the above-mentioned compounds is discussed.

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