Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Using Boc or Fmoc-protected β-substituted aminoethanesulfonyl chlorides (2 substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.

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