Design, synthesis, and antitumor activity of bicyclic and isomeric analogues of illudin M

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Novel bicyclic and isomeric analogues of the cytotoxic sesquiterpene illudin M were prepared using 1,3-dipolar cycloaddition reactions. Nearly every analogue investigated demonstrated low micromolar IC50 values when tested in a panel of four human tumor cell lines.

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