Synthesis and anti-HIV activity of dihydroisoxazole 6-chloropurine and adenine

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Dihydroisoxazole 6-chloropurine and adenine were efficiently prepared via 1,3-dipolar cycloaddition reaction of a nitrile oxide with vinyl 6-chloropurine, and found to be moderately effective against HIV-1 in acutely infected primary human lymphocytes.

Knowledge Graph

Similar Paper