Novel imidazothioxanthones: Synthesis, DNA binding and cytotoxicity

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

A new class of DNA-binding ligands (10a-t) has been synthesized and examined for DNAbinding affinity using thermal denaturation and for in vitro cytotoxicity in a number of cell lines. All the compounds were found to possess significant DNA-binding affinity which correlates with in vitro cytotoxicity across eight cell lines. Copyright © 1996 Elsevier Science Ltd

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