Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

Mono and bis double ester prodrugs of aminomethyl THF l~methylcarbapenems 1 were synthesized. Mono double ester derivatives (2, 4 and 7) did not demonstrate significantly improved oral activity due to the presence of the charged species. However, bis double ester derivatives (3 and 5) demonstrated enhanced oral activity.

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