The synthesis and evaluation of functionalized estratropones: Potent inhibitors of tubulin polymerization

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

The synthesis of several a-substituted estratropones is described. The compounds were evaluated for the inhibition of tubulin polymerization using purified bovine brain tubulin. Several of the compounds are equipotent to colchicine for their ability to inhibit the polymerization of tubulin. © 1997 Elsevier Science Ltd.

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