Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 -2 pg/mL) against MRSA and excellent stability in human plasma.

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