Novel cyanoguanidines with potent oral antitumour activity

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

4-Pyridyl cyanoguanidines with hydrophobic aromatic side chains showed potent antiproliferative activity in the human breast and lung cancer cell lines MCF-7, NYH and H460. In vivo, treatment with N-(6 chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine (18, 20 mg/kg/day po.), gave a complete remission of turnouts in a model of NYH inoculated nude mice.

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