7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

The synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, l l-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays. © 1997 Elsevier Science Ltd.

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