Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid labile transferrin conjugates

Synthesis of new maleimide derivatives of daunorubicin and biological activity of acid labile transferrin conjugates Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion BR96 conjugates of highly potent anthracyclines Synthesis of daunorubicin analogs with novel 9-acyl substituents Synthesis and In vitro efficacy of acid-Sensitive poly(ethylene glycol) paclitaxel conjugates Enhanced antitumor properties of 3'-(4-morpholinyl) and 3'-(4-methoxy-1-piperidinyl) derivatives of 3'-deaminodaunorubicin Adriamycin analogs. 3. Synthesis of N-alkylated anthracyclines with enhanced efficacy and reduced cardiotoxicity Adriamycin analogs. 2. Novel anomeric ribofuranoside analogs of daunorubicin Probing the Cysteine-34 Position of Endogenous Serum Albumin with Thiol-Binding Doxorubicin Derivatives. Improved Efficacy of an Acid-Sensitive Doxorubicin Derivative with Specific Albumin-Binding Properties Compared to That of the Parent Compound The design, synthesis, and evaluation of two universal doxorubicin-linkers: Preparation of conjugates that retain topoisomerase II activity